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1.
Int J Biol Macromol ; 267(Pt 2): 131608, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38621558

RESUMEN

Amidoxime-based fiber adsorbents hold significant promise for uranium extraction. However, a notable issue is that these adsorbents primarily originate from synthetic polymer materials, which, aside from providing good mechanical support, have no other functions. In recent study, we shifted our focus to silk fiber (SF), a natural protein fiber known for its unique core-shell structure and rich amino acids. The shell layer, due to its abundant functional groups, makes it easily modifiable, while the core layer provides excellent mechanical strength. Leveraging these inherent properties, an amidoxime-based fiber adsorbent was developed. This adsorbent utilizes amino and carboxyl groups for enhanced performance synergistically. This method involves establishing uranium affinity sites on the outer sericin layer of SF via chemical initiation of graft polymerization (CIGP) and amidoximation (SF-g-PAO). The water absorption ratio of SF-g-PAO is as high as 601.16 % (DG = 97.17 %). Besides, SF-g-PAO demonstrates an exceptional adsorption capacity of 15.69 mg/g in simulated seawater, achieving a remarkable removal rate of uranyl ions at 95.06 %. It can withstand a minimum of five adsorption-elution cycles. Over a 4-week period in natural seawater, SF-g-PAO displayed an adsorption capacity of 4.95 mg/g. Furthermore, SF-g-PAO also exhibits impressive uranium removal efficiency in real nuclear wastewater, with a removal rate of 63 % in just 15 min and a final removal rate of 90 %. It is hoped that this SF-g-PAO, prepared through this straightforward method and characterized by the synergistic action of amino and carboxyl groups, can offer innovative insights into the development of uranium extraction adsorbents.


Asunto(s)
Oximas , Seda , Uranio , Uranio/química , Adsorción , Oximas/química , Seda/química , Fibroínas/química
2.
Int J Biol Macromol ; 266(Pt 2): 131094, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38537852

RESUMEN

Konjac glucomannan (KGM) hydrolysate exhibit various biological activities and health-promoting effects. Lytic polysaccharide monooxygenases (LPMOs) play an important role on enzymatic degradation of recalcitrant polysaccharides to obtain fermentable sugars. It is generally accepted that LPMOs exhibits high substrate specificity and oxidation regioselectivity. Here, a bacteria-derived SmAA10A, with chitin-active with strict C1 oxidation, was used to catalyse KGM degradation. Through ethanol precipitation, two hydrolysed KGM components (4 kDa (KGM-1) and 5 kDa (KGM-2)) were obtained that exhibited antibacterial activity against Staphylococcus aureus. In natural KGM, KGM-1, and KGM-2, the molar ratios of mannose to glucose were 1:2.19, 1:3.05, and 1:2.87, respectively, indicating that SmAA10A preferentially degrades mannose in KGM. Fourier-transform infrared spectroscopy and scanning electron microscopy imaging revealed the breakage of glycosylic bonds during enzymatic catalysis. The regioselectivity of SmAA10A for KGM degradation was determined based on the fragmentation behaviour of the KGM-1 and KGM-2 oligosaccharides and their NaBD4-reduced forms. SmAA10A exhibited diverse oxidation degradation of KGM and generated single C1-, single C4-, and C1/C4-double oxidised oligosaccharide forms. This study provides an alternative method for obtaining KGM degradation components with antibacterial functions and expands the substrate specificity and oxidation regioselectivity of bacterial LPMOs.


Asunto(s)
Antibacterianos , Mananos , Oxigenasas de Función Mixta , Oxidación-Reducción , Mananos/química , Mananos/metabolismo , Antibacterianos/farmacología , Antibacterianos/química , Antibacterianos/metabolismo , Oxigenasas de Función Mixta/metabolismo , Oxigenasas de Función Mixta/química , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/enzimología , Especificidad por Sustrato , Hidrólisis
3.
Forensic Sci Int ; 345: 111606, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36857988

RESUMEN

HPLC-MS/MS analysis and postmortem distribution or postmortem redistribution of paraquat and its two metabolites in poisoning death cases were reported. Paraquat, monoquat, and paraquat monopyridone were extracted from the sample with acetonitrile or methanol, respectively, detected by ZORBAX HILIC Plus (4.6 × 100 mm, 3.5 µm) chromatographic column, with 0.1 % formic acid aqueous solution - 0.1 % formic acid acetonitrile solution (v/v) as mobile phase. Paraquat, monoquat, and paraquat monopyridone had a good linear relationship within the range of 10-1000, 1-400, and 1-1000 ng/mL (or g), the correlation coefficient (r) were all ≥ 0.9996. Their detection limits were lower than 1 ng/mL (or g). The detection accuracy was 91.25∼113.44 %. The intra-day and inter-day precision were 1.51-3.99 % and 1.92-4.93 %, respectively. This method was used to detect and analyze four rare paraquat poisoning cases. The distribution of paraquat, monoquat, and paraquat monopyridone is uneven, which is relatively high in the heart, blood, lung, and kidney. Heart blood/Peripheral blood ratio of paraquat, monoquat, paraquat monopyridone concentration in two poisoned cases were 1.4, 2.0, 1.5 and 1.9, 1.3, 1.2, which showed a location dependent postmortem redistribution. This is the first time that HPLC-MS/MS and the postmortem distribution or postmortem redistribution of paraquat metabolites in poisoned death cases have been reported. This research provides scientific basis for forensic identification of paraquat poisoning cases and extraction of biological specimen.


Asunto(s)
Paraquat , Espectrometría de Masas en Tándem , Cromatografía Líquida de Alta Presión/métodos , Espectrometría de Masas en Tándem/métodos , Formiatos
4.
Carbohydr Polym ; 278: 118918, 2022 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-34973737

RESUMEN

Yak milk (YM) has higher protein content than other bovine milk (BM) varieties. The bioactivity of milk glycoproteins is related to N/O-glycans. We qualitatively and quantitatively compared the N/O-glycome of YM and BM glycoproteins using stable isotope labeling combined with hydrophilic interaction chromatography and electrospray ionization mass spectrometry. We identified 79 and 78 N-glycans in YM and BM, respectively. Two N-glycans (H4N5F1A1; H5N4F1) were exclusive to YM. The content ratios of different types of N-glycans differed significantly between YM and BM, with sialylated N-glycans 2.33 times more abundant in YM. Five and seven O-glycans were detected in YM and BM, respectively. Two O-glycans (H1N2; H1N2A1) were exclusive to BM. The bi-sialylated O-glycan, H1N1A2, accounted for 56.1% of O-glycans in YM; it was 5.97 times more abundant in YM than in BM (equal volume basis). This study provides a theoretical basis for the future utilization of YM as a functional food.


Asunto(s)
Glicoproteínas/química , Leche/química , Polisacáridos/análisis , Animales , Bovinos , Cromatografía Liquida , Modelos Moleculares , Espectrometría de Masa por Ionización de Electrospray , Espectrofotometría Ultravioleta , Espectrometría de Masas en Tándem
5.
ACS Omega ; 6(44): 29675-29684, 2021 Nov 09.
Artículo en Inglés | MEDLINE | ID: mdl-34778639

RESUMEN

Owing to many problems of the detriment by large amount of organic reagents, high cost and difficulty of industrialization, development of high-efficiency economical technologies for uranium extraction is an irresistible trend to support steady supply of nuclear energy. Herein, a novel fibrous adsorbent, named as AO-HPE fibers, was prepared by introduction of amidoxime groups using the green vapor-phase grafting polymerization (VPGP) technology of monomer acrylonitrile (AN). Gaseous AN was grafted onto the ultra high molecular weight polyethylene (UHMWPE) fibers at 80 °C in the enclosed evaporation and condensation reflux system. The innovative technology not only endowed synthetic process high monomer utilization ratio but also excellent environmental friendliness. The AO-HPE fibers exhibited an appreciable calculated maximum adsorption capacity (Q m) of 1144.94 mg·g-1 in uranium solution and an adsorption capacity of 14.11 mg·g-1 in simulated seawater. Meanwhile, the higher uranium selectivity than main competing ion vanadium (adsorption mass ratio was almost 5) was achieved. The adsorption process accorded closely with chemisorption mechanism. This work provided a novel idea for the synthetic method of adsorbents for uranium extraction, and inspired the sustainable technologies for grafting polymerization of monomer AN.

6.
ACS Appl Mater Interfaces ; 13(48): 57831-57840, 2021 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-34807567

RESUMEN

Metal-organic frameworks (MOFs) with a high surface area and excellent stability are potential candidates for uranium (U) adsorption. Amidoxime (AO) is the most widely used functional group to extract U, which is usually introduced into MOFs by two-step post-synthetic methods (PSMs). Herein, MOF UiO-66-NH-(AO) was obtained by a one-step PSM with amidoximation from UiO-66-NH-(CN), which was synthesized by a new organic ligand of 2-cyano-terephthalic acid and whose morphology was octahedron and could be well controlled with the new ligand. The one-step PSM can greatly maintain the octahedron of the MOFs. What is more, UiO-66-NH-(AO) showed good adsorption performance for U, the adsorption equilibrium was obtained within 1500 min, and the adsorption capacity of U was calculated to be 134.1 mg/g according to the Langmuir model. It also had excellent selectivity for U in the presence of high concentrations of vanadium (V), ferrum (Fe), magnesium (Mg), calcium (Ca), and zirconium (Zr). The adsorption capacity of U in natural seawater was determined to be 5.2 mg/g within 8 days. The recyclability of UiO-66-NH-(AO) in simulated seawater was demonstrated for at least four adsorption/desorption cycles. The binding mechanism was investigated by the extended X-ray absorption fine structure spectroscopy, revealing that U binding occurs in a fashion η2 motif. This study provides a reliable idea for the modification of MOFs and the potential for MOF-based materials to extract U from seawater.

7.
Ecotoxicol Environ Saf ; 203: 111021, 2020 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-32888607

RESUMEN

Volatile iodine released from nuclear power plant reactors is radiological hazard to environment and human's health because of their high fission yield and environmental mobility. The complexity of nuclear waste management motivated the development of solid-phase adsorbents. Herein, co-radiation induced graft polymerization (CRIGP) was employed in the graft polymerization of N-vinyl-2-pyrrolidone (NVP) onto polyethylene-coated polypropylene skin-core (PE/PP) fibers using electron beam (EB) irradiation. This work provides a one-step green synthetic approach to prepare iodine fibrous adsorbents without any chemical initiators or large amount of organic solvent. The original and modified PE/PP fibers were characterized by fourier transform infrared spectrometry (FTIR), X-ray photoelectron spectroscopy (XPS), thermogravimetric (TG) and scanning electron microscopy (SEM) to demonstrate the grafting of NVP onto the PE/PP fibers. The capacity of iodine absorbed by the PE/PP-g-PNVP fibers was 1237.8 mg/g after 180 min. Meanwhile, absorbents can be regenerated efficiently by two different means of ethanol elution and heating at 120 °C, respectively. Within 10 min, 94.17% and 90.12% of the iodine can be released from the PE/PP-g-PNVP fibers with these two methods, respectively. The adsorbent exhibited a long service life of at least ten adsorption-desorption cycles, suggesting that PE/PP-g-PNVP fibers might be a promising adsorbent for volatile iodine adsorption from fission products in nuclear power plant reactors.


Asunto(s)
Contaminantes Radiactivos del Aire/análisis , Rayos gamma , Tecnología Química Verde/métodos , Yodo/análisis , Polipropilenos/química , Pirrolidinonas/química , Adsorción , Humanos , Cinética , Polimerizacion , Polipropilenos/efectos de la radiación , Pirrolidinonas/efectos de la radiación , Propiedades de Superficie
8.
Materials (Basel) ; 13(13)2020 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-32630807

RESUMEN

Herein, adsorption, separation, and reduction of Au(III) from its aqueous solution were studied with different amine-type, non-woven fabric (NF) adsorbents fabricated with radiation-induced graft polymerization. The adsorbents exhibited different adsorption capacities of Au(III) over a concentration range of hydrochloric acid (HCl) from 5 mM to 5 M, and the diethylamine (DEA)-type adsorbent performed best under all test conditions. The DEA-type adsorbent was inert toward other metal ions, including Cu(II), Pb(II), Ni(II), Zn(II) and Li(I), within the fixed concentration range of HCl. Flow-through adsorption tests indicated DEA-type adsorbent exhibited a rapid recovery and high adsorption capacity of 3.23 mmol/g. Meanwhile, DEA-type adsorbent also exhibited high selectivity and rapid extraction for Au(III) from its mixed solution with Pt(IV) and Pd(II). After adsorption, the reduction of Au(III) was confirmed by XRD spectra, TEM, and digital micrograph images. The results indicated that nano-sized Au particles were mainly concentrated on the adsorbent in 5 mM HCl solution. In 1 M HCl solution, not only nano-sized Au particles were found, but also micro-size Au plates precipitation occurred. This study provides a novel material for selective and efficient gold uptake from aqueous solution.

9.
Biotechnol J ; 15(2): e1900107, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31473998

RESUMEN

Extracellular vesicles (EVs) from cancer cells remodel distant organs to promote metastasis in vivo. A biomimetic microsystem may compensate costly and time-consuming animal models to accelerate the study of EV organotropism. A tissue-based liver-kidney-on-a-chip is developed with precision-cut tissue slices (PTSs) cultured to represent individual organs. The organotropism of breast cancer EVs is modeled using the biomimetic microsystem. A traditional animal model of EV organotropism is used to investigate the physiological similarity of the microfluidic model to animal models. It is demonstrated that breast cancer EVs show strong liver tropism rather than kidney tropism on both the microfluidic and animal models. It is found that the metastatic inhibitor AMD3100 inhibits liver tropism effectively in both the microfluidic and animal models. Overall, the tropism of EVs to different organs is reconstituted on the microfluidic model. The liver-kidney-on-a-chip may expand the capabilities of traditional cell culture models and provide a faster alternative to animal models for EV studies.


Asunto(s)
Neoplasias de la Mama/patología , Dispositivos Laboratorio en un Chip , Tropismo/efectos de los fármacos , Animales , Bencilaminas , Biomimética , Neoplasias de la Mama/tratamiento farmacológico , Ciclamas , Vesículas Extracelulares/patología , Femenino , Compuestos Heterocíclicos/farmacología , Humanos , Riñón/patología , Hígado/patología , Microfluídica , Metástasis de la Neoplasia , Análisis de Secuencia por Matrices de Oligonucleótidos
10.
RSC Adv ; 9(49): 28588-28597, 2019 Sep 09.
Artículo en Inglés | MEDLINE | ID: mdl-35529616

RESUMEN

A novel uranium-imprinted adsorbent (AO-Imp fiber) was prepared by radiation-induced crosslinking of amidoxime-functionalized ultra-high molecular weight polyethylene fiber (AO fiber). The porous structure was characterized by scanning electron microscopy (SEM) and positron annihilation lifetime (PAL) spectroscopy after ion imprinting. This ion-imprinted fiber exhibited enhanced adsorption selectivity for uranium in the form of both UO2 2- and [UO2(CO3)3]4- in batch experiments. Compared with AO fiber, the adsorption capacity of the AO-Imp(250) fiber for uranium increased from 0.36 mg g-1 to 1.00 mg g-1 in simulated seawater and from 5.02 mg g-1 to 12.03 mg g-1 in simulated acid effluent, while its adsorption capacities for other co-existing metal ions were particularly low. This study provides an approach to prepare ion-imprinted adsorbents without introducing crosslinking reagents, which may be a promising method for uranium extraction.

11.
Molecules ; 23(6)2018 05 23.
Artículo en Inglés | MEDLINE | ID: mdl-29882863

RESUMEN

This work provides a cost-effective approach for preparing functional polymeric fibers used for removing uranium (U(VI)) from carbonate solution containing NaF. Phosphate-based ultrahigh molecular weight polyethylene (UHMWPE-g-PO4) fibers were developed by grafting of glycidyl methacrylate, and ring-opening reaction using phosphoric acid. Uranium (U(VI)) adsorption capacity of UHMWPE-g-PO4 fibers was dependent on the density of phosphate groups (DPO, mmol∙g−1). UHMWPE-g-PO4 fibers with a DPO of 2.01 mmol∙g−1 removed 99.5% of U(VI) from a Na2CO3 solution without the presence of NaF. In addition, when NaF concentration was 3 g∙L−1, 150 times larger than that of U(VI), the U(VI) removal ratio was still able to reach 92%. The adsorption process was proved to follow pseudo-second-order kinetics and Langmuir isotherm model. The experimental maximum U(VI) adsorption capacity (Qmax) of UHMWPE-g-PO4 fibers reached 110.7 mg∙g−1, which is close to the calculated Qmax (117.1 mg∙g−1) by Langmuir equation. Compared to F−, Cl−, NO3−, and SO4²− did not influence U(VI) removal ratio, but, H2PO4− and CO3²− significantly reduced U(VI) removal ratio in the order of F− > H2PO4− > CO3²−. Cyclic U(VI) sorption-desorption tests suggested that UHMWPE-g-PO4 fibers were reusable. These results support that UHMWPE-g-PO4 fibers can efficiently remove U(VI) from carbonate solutions containing NaF.


Asunto(s)
Carbonatos/química , Fluoruros/análisis , Fosfatos/química , Polietilenos/química , Uranio/aislamiento & purificación , Adsorción , Cinética , Peso Molecular , Espectroscopía de Fotoelectrones , Soluciones , Espectroscopía Infrarroja por Transformada de Fourier
12.
Pest Manag Sci ; 74(1): 189-199, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-28762622

RESUMEN

BACKGROUND: Agrochemicals have been crucial to the production of food, and the need for the development of novel agrochemicals continues unceasing owing to the loss of existing produces via the growth of resistance and the desire for products with more propitious environmental and toxicological patterns. RESULTS: The results of both CoMFA and CoMSIA models indicated that biological activity can effectively be improved through the structural optimisation and molecular design of these synthetic compounds from the aspects of steric, electrostatic, hydrophobic, hydrogen bond donor and acceptor fields. Data of postemergence herbicidal activity in the greenhouse explained that most new 3-(pyridin-2-yl)benzenesulfonamide derivatives (4c-4 t) could control highly effectively against barnyardgrass, foxtail, vetleaf, and youth and old age (herbicidal activity ≥90%); for example, compounds 4q-4 t exhibit excellent biological activity equivalent/superior to commercial saflufenacil/sulcotrione at the low concentration of 37.5 g a.i./ha, and in particular, the herbicidal activity of compound 4 t for four experimental plant species is found to be notably greater than saflufenacil (3.75 g a.i./ha). Meanwhile, compound 4 t also has good crop selectivity for weed control in maize. CONCLUSION: The novel compounds such as 4 t have remarkable biological activity after the structural optimisation utilising the constructed 3D-QSAR models, i.e. such QSAR models have great accuracy. © 2017 Society of Chemical Industry.


Asunto(s)
Herbicidas/farmacología , Poaceae/efectos de los fármacos , Diseño de Fármacos , Herbicidas/química , Modelos Moleculares , Relación Estructura-Actividad Cuantitativa , Sulfonamidas/química , Bencenosulfonamidas
13.
Pestic Biochem Physiol ; 143: 246-251, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29183599

RESUMEN

A series of novel quaternary ammonium salt derivatives were designed and synthesized by introducing the herbicide carboxylic acid into substituted aminoacetanilide compounds which derived from herbicides alachlor or acetochlor, using the intermediate derivatization methods in an attempt to obtain novel candidates for weed control. The herbicidal activity assays in greenhouse demonstrated that some of the title compounds exhibited good herbicidal activities against velvet leaf, youth-and-old age, barnyard grass, and foxtail. Especially, III9 gave the best activity (EC50 (ga.i/ha): YOA 34.1, VEL 33.6, FOX 15.9, BYG 36.2). The field trials indicated that III9 had better herbicidal activity than the commercial herbicide imazethapyr to control broadleaf weeds at 150ga.i/ha. The present work demonstrated that the quaternary ammonium salt derivatives can be used as potential lead compounds for discovering novel herbicides with improved activity. III9 itself is worthy of being further developed as an herbicidal candidate. Further syntheses, structure optimization studies, and field trials around III9 are in progress.


Asunto(s)
Compuestos de Amonio/toxicidad , Herbicidas/toxicidad , Magnoliopsida/efectos de los fármacos , Malezas/efectos de los fármacos
14.
Pestic Biochem Physiol ; 142: 155-160, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-29107240

RESUMEN

Benzoylcyclohexanedione herbicides work by inhibiting 4-hydroxyphenylpyruvate dioxygenase which was the last new target site introduced for herbicides. In an attempt to find new 4-hydroxyphenylpyruvate dioxygenase inhibitors with high efficacy and selectivity, a novel benzoylcyclohexanedione compound SYP-9121 was synthesized and studied in greenhouse and field. In the greenhouse, SYP-9121 showed broad spectrum herbicidal activity and good safety to maize. Its control of barnyard grass, crabgrass, redroot pigweed, purslane, dayflower and night shade was equivalent to that of the commercial herbicide mesotrione. Three field trials in summer maize showed that SYP-9121 could efficiently control both grass and broadleaf weeds with good selectivity. Herbicidal activity of SYP-9121 was comparable to that of mesotrione.


Asunto(s)
Herbicidas/síntesis química , Herbicidas/farmacología , 4-Hidroxifenilpiruvato Dioxigenasa/antagonistas & inhibidores , 4-Hidroxifenilpiruvato Dioxigenasa/metabolismo , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/farmacología , Herbicidas/química , Estructura Molecular , Proteínas de Plantas/antagonistas & inhibidores , Proteínas de Plantas/metabolismo , Malezas/efectos de los fármacos , Malezas/enzimología , Malezas/crecimiento & desarrollo , Relación Estructura-Actividad , Zea mays/efectos de los fármacos , Zea mays/enzimología , Zea mays/crecimiento & desarrollo
15.
Conserv Biol ; 31(5): 1173-1182, 2017 10.
Artículo en Inglés | MEDLINE | ID: mdl-28221696

RESUMEN

Scientists increasingly rely on protected areas to assist in biodiversity conservation, yet the efficacy of these areas is rarely systematically assessed, often because of underfunding. Still, adaptive management strategies to maximize conservation success often rely on understanding the temporal and spatial dynamism of populations therein. Examination of environmental DNA (eDNA) is a time and cost-effective way to monitor species' distribution, and quantitative polymerase chain reaction (qPCR) provides information on organismal abundance. To date, however, such techniques remain underused for population assessments in protected areas. We determined eDNA concentration of the critically endangered Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) to describe its occurrence, range, and use of the Tian e-Zhou National Nature Reserve in Hubei, China, across seasons and hydrological depths. Despite the observation that total eDNA concentrations were highest in surface waters in summer, finless porpoise eDNA concentrations were significantly higher in deeper waters than in surface waters in summer. During the breeding season (spring), eDNA signals were site specific and restricted to the core area of the reserve. However, postbreeding eDNA concentrations were widespread across the reserve, encompassing sites previously thought to be unfrequented by the species. Our results suggest spatiotemporal idiosyncrasies in site, depth, and seasonal use of the reserve and a propensity for postbreeding population dispersal. With eDNA and qPCR we were able to assess an entire population's use of a protected area. Illuminating nuances in habitat use via eDNA could be valuable to set pragmatic conservation goals for this, and other, species.


Asunto(s)
Conservación de los Recursos Naturales , ADN/análisis , Marsopas/genética , Animales , Biodiversidad , China
16.
International Eye Science ; (12): 2354-2355, 2017.
Artículo en Chino | WPRIM (Pacífico Occidental) | ID: wpr-669371

RESUMEN

·AIM: To discuss the cause of lacrimal duct obstruction relapsed after lacrimal duct stent operation.·METHODS:A total of 523 patients(523 eyes) of lacrimal duct obstruction were enrolled. They were given regular examination of the eyes and nose before lacrimal duct stent operation. We analyzed the correlation between the lacrimal duct obstruction and the relevant disease. And 280 cases reoccurred lacrimal duct obstruction during the average 2a follow-up. The causes correlated with the relapsed obstruction were assessed.·RESULTS: Lacrimal duct obstruction mostly occurred secondary to the inflammation of conjunctiva or nasal mucosa. The upper site obstruction correlated with the chronic conjunctivitis, while the lower site obstruction related to the hypertrophy of inferior turbinate. Outcome of some cases were discouraging after the stents removed. The removal of the ring silicone tube usually leaded to the upper site obstruction, while the lower site obstruction usually caused by the removal of spherical silicone tube.· CONCLUSION: Lacrimal duct stent operation is a simple, safe and outpatient treatment. But the long-term effectiveness is not encouraging. We should make personal treatment according to the etiological factor, the site of the obstruction, age, and the procedure of treatment.

17.
Sci Rep ; 6: 22796, 2016 Mar 07.
Artículo en Inglés | MEDLINE | ID: mdl-26948405

RESUMEN

The prevention of refractory organic pollution caused by conventional dyeing and the development of new fabrics with various functions are two issues to be solved urgently in the field of textile fabrication. Here, we report a new environmentally friendly route for the simultaneous coloration and functionalization of textiles by the covalent immobilization of a metal-organic framework, Cr-based MIL-101(Cr), onto the surfaces of nylon fabrics by co-graft polymerization with 2-hydroxyethyl acrylate initiated by γ-ray irradiation. The Cr(III) clusters color the nylon fabric, and the color intensity varies with the MIL-101 content, providing a "green" textile coloration method that is different from conventional dyeing processes. An X-ray diffraction (XRD) analysis shows that the nanoporous structure of the original MIL-101 particles is retained during radiation-induced graft polymerization. Numerous nanopores are introduced onto the surface of the nylon fabric, which demonstrated better sustained-release-of-aroma performance versus pristine nylon fabric in tests. The modified fabrics exhibit laundering durability, with MIL-101 nanoparticles intact on the nylon surface after 30 h of dry cleaning.

18.
Bioorg Med Chem ; 24(3): 428-34, 2016 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-26385445

RESUMEN

In an attempt to obtain novel candidate compound for weed control, a series of newly substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives 2 were designed and synthesized using compound II7 as a lead compound by Intermediate Derivatization Methods and their herbicidal activities were evaluated. The herbicidal activity assay in greenhouse tests showed several compounds (2g, 2i, 2j, 2k, 2l, 2m, 2n and 2o) exhibited significant herbicidal activity for controlling velvet leaf (Abutilon theophrasti medic.) and youth-and-old age (Zinnia elegans jacq.) at 37.5ga.i./ha. In particular, 2h was found to be the most potential candidate herbicide and was proved higher activity than the lead compound II7. The result of the weed controlling spectrum test showed that 2h could effectively control dayflower (Commelina tuberosa), bur beggarticks (Bidens tripartita linn.), youth-and-old age, cassia tora (Cassiaobtusifolia L.), velvet leaf, purslane (Portulaca oleracea) and false daisy (Eclipta prostrata L.). In addition, the mixture of compound 2h and propanil could produce a synergistic effect and enhance herbicidal activity. The result of the herbicidal activity assay in field test demonstrated that 2h could effectively control dayflower and nightshade (Disambiguation) with long-lasting persistence. The present work indicates that 2h may be a novel compound candidate as a potential herbicide.


Asunto(s)
Glicina/análogos & derivados , Herbicidas/farmacología , Plantas/efectos de los fármacos , Sulfonamidas/farmacología , Relación Dosis-Respuesta a Droga , Glicina/síntesis química , Glicina/química , Glicina/farmacología , Herbicidas/síntesis química , Herbicidas/química , Estructura Molecular , Relación Estructura-Actividad , Sulfonamidas/síntesis química , Sulfonamidas/química
19.
ACS Appl Mater Interfaces ; 7(32): 17558-64, 2015 Aug 19.
Artículo en Inglés | MEDLINE | ID: mdl-26226281

RESUMEN

Herein, we first reported a facile strategy to prepare functional Poly(vinyl alcohol) (PVA) hybrid film with well ultraviolet (UV) shielding property and visible light transmittance using graphene oxide nanosheets as UV-absorber. The absorbance of ultraviolet light at 300 nm can be up to 97.5%, while the transmittance of visible light at 500 nm keeps 40% plus. This hybrid film can protect protein from UVA light induced photosensitive damage, remarkably.


Asunto(s)
Grafito/química , Nanoestructuras/química , Protectores Solares/química , Rayos Ultravioleta , Electroforesis en Gel de Poliacrilamida , Muramidasa/química , Muramidasa/metabolismo , Óxidos/química , Alcohol Polivinílico/química , Espectrofotometría Ultravioleta
20.
Sci Rep ; 5: 11255, 2015 Jun 12.
Artículo en Inglés | MEDLINE | ID: mdl-26066704

RESUMEN

There is growing interest in the area of conductive textiles in the scientific and industrial community. Herein, we successfully prepared a conductive textile via covalently grafting polyaniline (PANI) onto cotton by a multi-step treatment process. The conductivity of the resultant fabric could be tuned by immersing in water having different pH values. The conductive and insulating properties of the textile could be conveniently switched by alternately immersing in acidic and alkaline bath solutions. Most importantly, the resultant conductive fabrics were able to withstand 40 simulated dry-wash cycles, with almost no decay in the electrical conductivity, indicating their excellent dry-wash durability. The present strategy for fabricating conductive fabrics with excellent switchability of electrical properties and dry-wash durability is expected to provide inspiration for the production of multifunctional conductive textiles for use in hash or sensitive conditions.

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